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KMID : 0380020120270050273
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Korean Journal of Biotechnology and Bioengineering
2012 Volume.27 No. 5 p.273 ~ p.280
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The Use of Graphene for Regenerative Medicine
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Yoon Jeong-Kee
Kim Byung-Soo
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Abstract
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Graphene is a one-atom-thick sheet composed of carbon atoms only. It has a two-dimensional honeycomb structure with sp2 orbital bonding, which presents some unique properties. Due to large Young's modulus, good electrical conductivity, ability to immobilize several kinds of small molecules and proteins, and biocompatibility of graphene, it has attracted interests inits ability to enhance cell growth and differentiation, followed by recent several studies. We reviewed about the osteogenic differentiation of mesenchymal stem cells, and neurogenic differentiation of neuron stem cells, and the ectodermal and mesodermal differentiation of induced pluripotent stem cells using graphene. Graphene has not only enhanced the adhesion and proliferation of mesenchymal stem cells, but also led to the faster differentiation even without any other exogenous signals. Nonetheless, graphene has some cytotoxicities in its amount-response manner, which is critical to regenerative medicine. The cytotoxicities of graphene were compared with those of grapheneoxide and carbon nanotubes.
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KEYWORD
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Graphene, Osteogenesis, Neurogenesis, Induced Pluripotent Stem Cells, Cytotoxicity
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